volker schulz and Rudolf Hansel See book keywords and concepts | Sect. 1.2). mSJ| Side Effects and Risks
In an observation of 4049 patients who took 105 mg/day of an extract standardized to 70 % kavapyrones for 7 weeks, objectionable side effects were documented in 61 patients, representing an incidence of 1.5 %. The side effects were mild in nature and reversible. Most consisted of gastrointestinal complaints or allergic skin reactions. A 4-week study in 3029 patients who took 800 mg/day of an extract standardized to 30 % kavapyrones (= 240 mg kavapyrones) showed a 2.3 % incidence of unpleasant side effects. | Gary Null and Amy McDonald See book keywords and concepts | Koetter U; Schrader E; et al. phytotherapy Research. 2007 May 8.
A fixed valerian hops extract combination was found to be more effective than placebo in reducing sleep latency in people with insomnia. A single valerian extract did not achieve the same results, indicating that the addition of hops is important.
Clinical Efficacy of Kava Extract WS 1490 in Sleep Disturbances Associated with Anxiety Disorders. Results of a Multicenter, Randomized, Placebo-Controlled, Double-blind Clinical Trial. Lehrl S. Journal of 'Affective Disorders, 2004 February, 78(2): 101-110. | Geier FP; Konstantinowicz T. phytotherapy Research, 2004 April,18(4):297-300.
This placebo-controlled double-blind study was designed to examine the dosage range and efficacy of kava special extract WS 1490 in patients with nonpsychotic anxiety. Results indicated that 150 mg per day was well tolerated with no adverse effects.
Kava-Kava Extract LI 150 is As Effective As Opipramol and Buspirone in Generalised Anxiety Disorder—An 8-week Randomized, Double-blind Multi-centre Clinical Trial in 129 Out-patients. Boerner RJ; Sommer H; et al. Phytomedicine, 2003, 10 (Suppl. 4):38-49. | Joerg Gruenwald, Ph.D. See book keywords and concepts | Hiller KO, Zetler G, (1996) Neuropharmacological Studies on Ethanol Extracts of Valeriana officinalis: Behavioural, Anticonvulsant Properties. phytotherapy Res 10:145-151.
Hiller KO, Kato G, Anxiolytic activity of psychotropic plant extracts. I. Test of ethanolic Valeriana extract STEI Val. In: PM 62, Abstracts of the 44th Ann Congress of GA, 65. 1996.
Hiller KO, Rahlfs V, Therapeutische Aquivalenz eines hochdosierten Phytopharmakons mit Amytriptylin bei angstlich-depressiven Versimmungen - Reanalyse einer randomisierten Studie unter besonderer Beachtung biometrischer und klinischer Aspekte. | LITERATURE
Adamek B, Drozdzik M, Samochowiec L, Wojcicki J, Clinical effect of buckwheat herb, Ruscus extract and troxerutin on retinopathy and lipids in diabetic patients. In: phytotherapy Res 10(8):659-662. 1996.
Bombardelli E et al., (1972) Fitoterapia 43:3.
Dunaouau CH et al., Triterpenes and sterols from Ruscus aculeatus. In: PM 62(2): 189-190. 1997.
Rauwald HW, Janfien B, Desglucoruscin and Desglucoruscosid als Leitstoffe des Ruscus-aculeatus-Wurzelstock. Analytische Kennzeichnung mittel HPLC und DC. In: PZW 133(l):61-68. 1988. | LITERATURE
Adamek B, Drozdzik M, Samochowiec L, Wojcicki J, Clinical effect of buckwheat herb, Ruscus extract and troxerutin on retinopathy and lipids in diabetic patients. In: phytotherapy Res 10(8):659-662. 1996.
Anonym, Nicht-Brotgetreidearten: Alternative Korner unter der Lupe. In: DAZ 136(38):3229-2330. 1996.
Bassler R, PA 12:758-772 et 834-841. 1985.
Couch JF, Naghski J, Krewson CF, Science 103:197-198. 1974.
Gaidies I, Buchweizen, eine Venenhilfe. In: PTA 6(7):439. 1992.
Hagels H et al, Two anthraquinones and a bianthraquinone from Fagopyrum tataricum. | Dr. Michael Heinrich, Joanne Barnes, Simon Gibbons and Elizabeth M. Williamson See book keywords and concepts | CAM.
MEDICAL HERBALISM History
Medical herbalism - the use of plant remedies in the prevention and treatment of illness - has a history as long as that of mankind. In the UK, it has a historical basis partly in the Galenical model of 'body humours' (blood, black bile, yellow bile, phlegm), their 'temperaments' (e.g. hot, cold, damp) and the belief that illness resulted from an imbalance in these humours. | Amarjit S. Basra See book keywords and concepts | The assessment of the efficacy of phytopreparations by placebo-controlled double-blind trials with bioavailability and pharmacokinetic studies holds the key for a rational and fully accepted phytotherapy.
NOTES
1. Nettleton, D.E., 1996, Phytomedicine in Europe: Their chemistry and biological activity, Drugs of the Future, 21(12): 1257-1264.
2. Cragg, G.M., Newman, D.J., and Snader, K.M., 1997, Natural products in drug discovery and development, J. Nat. Prod., 60: 52-60.
3. Shu, Y.-Z., 1998, Recent natural products based drug development: A pharmaceutical industry perspective, J. Nat. Prod. | Garlic and neem leaf extracts enhance hepatic glutathione and glutathione dependent enzymes during N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced gastric carcinogenesis in rats, phytotherapy Research, 14(4): 291-293; Arivazhagan, S., Nagini, S., Santhiya, S.T., and Ramesh, A., 2001, Protection of N-methyl-N'-nitro-N-nitrosoguanidineinduced in vivo clastogenicity by aqueous garlic extract, Asia Pacific Journal of Clinical Nutrition, 10(3): 238-241.
127. Mostafa, M.G., Mima, T., Ohnishi, ST.. and Mori. K. | FUTURE NEEDS: phytotherapy AND THE CONCEPT OF ETHNOPHARMACY
For many centuries, ethnobotany played an important role in the development of new useful products. As shown in this contribution and the other ones in this book, nature-derived drugs as well as phytomedicines are still important in pharmacy. Today the consumer demand for natural medicines is higher than it was ever before. Both in Europe and in the United States consumers spend at least $4 billion a year on herbal medicinal products. | Two paradigm shifts, exemplified by the following changes in chemo-therapeutic strategies, serve as additional confirmation and legitimization of phytomedicinal research and phytotherapy: a gradual renunciation of the long-standing reliance on monotherapy as an ideal, in favor of polychemotherapy and the development of totally new application concepts, through which the evaluation of different pathophysiological processes and accompanying symptoms, rather than the search for single disease-causing agents (e.g., tumor cells or infection), has assumed significance. | Michael T. Murray, N.D. See book keywords and concepts | Paper presented at the 4th International Congress on phytotherapy. Munich, Germany. September 10-13,1992. [Abstract SL53]; Woelk H: Multicentric practice-study analyzing the functional capacity in depressive patients. Paper presented at the 4th International Congress on phytotherapy. Munich, Germany. September 10-13,1992. [Abstract SL54J; Sommer H. Improvement of psychovegetative complaints by hypericum. Paper presented at the 4th International Congress on phytotherapy. Munich, Germany. September 10-13,1992. [Abstract SL55]
17. | Amarjit S. Basra See book keywords and concepts | Kovacs, E„ 2002, The in vitro effect of Viscum album (VA) extract on DNA repair of peripheral blood mononuclear cells (PBMC) in cancer patients, phytotherapy Research, 16(2): 143-147.
31. Klopp, R., Schmidt, W., Niemer, W., Werner, M., and Beuth, J., 2001. Changes in immunological characteristics of white blood cells after administration of standardized mistletoe extract, In Vivo, 15(6): 447-457.
32. Kovacs, E. | New drugs from plants: It could be yew. phytotherapy Res., 13: 1-7.
24. Tauchert, M., Block, M., and Hiibner, W.D., 1994, Wirksamkeit des Weitklorn-Extraktes LI 132 im Vergleich mit Captopril-Multizentrische Doppel-blindstudie bei 192 Patienten mit Herzinsuffizienz im Stadium II nach NYHA, Miinch. Med. Wschr., 136(Suppl. 1): 27-33; Tauchert, M., 2002. Efficacy and safety of Crataegus extract WS 1442 in comparison to placebo in patients with chronic stubel heart insufficiency at NYHA III, Am. Heart Journal, 143(5): 910-915.
25. Wagner, H., Elbl. G., Lotier, H., and Guinea, M. | Joseph E. Mario See book keywords and concepts | Fumaria
(from phytotherapy). Homeopathic: Potassium Arsenic, Potassium Bromine, Graphites (6x, for syphilitic psoriasis), and Sulfur (ifhot). Psorinum 200 (by physician only, used ifchilly). Color Therapy: Use the above aromatherapy, then Blue exposure for 30 minutes, and
Ultraviolet for 10min.twicedailyfor3-6months. SEESkin.
•PULMONARY EMBOLISM From an artery thrombus to a traveling embolism up through the right side ofthe heart to a lung artery, cutting offtissue blood. May occurafter surgery, pregnancy, pelvis and lowerextremity injury, bums, heartfailure. or prolonged bed-rest. | Dr. Gary Null See book keywords and concepts | Euphytose, an Association of Plant Extracts with Anxiolytic Activity: Investigation of its Mechanism of Action by an In Vitro Binding Study," phytotherapy Research 5 (1991): 241-44.
Passiflora edulis aqueous extract was the subject of a study involving rats, mice, and healthy human volunteers. It was shown to have a nonspecific depressant effect on the central nervous system, and not a hypnotic-sedative effect.
E. Maluf et al., "Assessment of the Hypnotic/Sedative Effects and Toxicity of Passiflora Edulis Aqueous Extract in Rodents and Humans," phytotherapy Research 5 (1991): 262-66. | Andrew Pengelly See book keywords and concepts | Ammi visnaga (Khella)', British
Journal of phytotherapy 1: 7-10. Harborne, J. and Baxter, H. 1993, Phytochemical Dictionary, Taylor &C
Francis, London.
Hikino, H. 1985, 'Chinese medicinal plants used against hepatitis', in H. M. Chang, H. W. Yeung, W.-W. Tso, A. Koo (eds), Advances in Chinese Medicinal Materials Research, World Scientific Pubs, Singapore.
Huang, K. C. 1993, The Pharmacology of Chinese Herbs, CRC Press, Boca Raton.
Johri, J. K, Banerji, R., Chaurasia, R. S., Misra, G, Siddigni, S. A., Balasubrahmanyam, V. R. and Nigam, S. K. | David Hoffman, FNIMH, AHG See book keywords and concepts | Practitioners of phytotherapy have the unique opportunity to introduce their patients to their medicine! A bridge can be built between person and herb, empowering the patient to be present and responsible in the healing process. A gift to a patient of a packet of herb seeds encourages a direct experience of the life of the plant. This experience of herbal vitality can turn an impersonal medicine into a living entity with which the individual can develop a deeper rapport. | However, this potential simply mirrors the therapeutic strengths of the whole plants, long recognized in traditional herbal medicine and its modern manifestation, phytotherapy.
While new research that points to potential applications for isolated flavonoids is exciting, it should not defleet the attention of the practitioner from the therapeutic cornucopia offered by the plants themselves.64 Traditional herbal and naturopathic protocols, often the cues that inspired the research in the first place, have great inherent value based on generations of observation and use. | As with most holistically oriented therapies, excellent results can be achieved with phytotherapy by focusing on factors that suggest causal links. Specific herbal remedies can prove exceptionally successful if used within a context that addresses the whole body and environment of the patient.
Common migraine may affect as many as 25% of Americans, and about 8% of all headaches treated by the average physician are migraines or some variation on migraines.7 Attacks can occur in early childhood, but most patients first develop symptoms between the ages of 10 and 30. | Mark Blumenthal See book keywords and concepts | A role for phytotherapy in the treatment of benzodiazepine and opiate drug withdrawal. Eur J Herb Med 1997;3:11-21.
Riedel E, Hansel R, Ehrke G. Inhibition of gamma-aminobutyric acid catabolism by valerenic acid derivatives. Planta Med 1982;48:219-20.
Rodenbeck A, Simen S, Cohrs S, et al. Alterations of the sleep stage structure as a feature of GABAergic effects of a valerian-hop preparation in patients with psychophysiological insomnia. Somnologie 1998;2:26-31.
Ruppanner H, Schaefer U (eds.). Codex 2000/01 — Die Schweizer Arzneimittel in einem Griff. Basel, Switzerland: Documed AG. 2000. | Marie-France Muller, M.D., N.D., Ph.D. See book keywords and concepts | PHYTOTHERAPY AND THE NUTRITIONAL PROPERTIES OF PLANTS
While the aromatic properties of plants are most often given the greatest consideration in phytotherapy, we must also acknowledge the other properties and constituents that plants contribute. Among these are vitamins, enzymes, minerals, and trace elements. It is more than likely that a large portion of the virtues of medicinal plants is due to their mineral content. Chamomile, for example, contains 1800 mg of potassium per 200 calories. In addition, 23 percent of its makeup is calcium. | Frantisek Stary See book keywords and concepts | Just as chemistry has untold possibilities of coming up with new and effective synthetic medicines, so phytotherapy has opportunities of discovering new natural medicines in the plant realm. Chemotherapy and phytotherapy are both effective if treatment is properly selected, and the two can also be successfully combined.
To date man has discovered only about 10 per cent of the many and diverse existing plant species and thus the prospects of research in the field of natural medicines are bright indeed. Antibiotics, hormones, vitamins, pros-taglandines ?all have their origin and basis in nature. | Josef A. Brinckmann and Michael P. Lindenmaier See book keywords and concepts | The ESCOP (European Scientific Cooperative for phytotherapy) has published separate monographs for Taraxaci folium and Taraxaci radix [11], wherein the leaf drug is indicated as an adjunct therapy for diseases where enhanced diuresis is desirable (e.g. prevention of renal gravel and rheumatism), and the root drug is indicated for loss of appetite, dyspepsia, and for restoration of disturbed hepatic and biliary function. Indications of the cholagogic and diuretic actions of the drug can be found in older animal experiments [12—15] and clinical studies [15, 16]. | Patrick Quillin, PhD,RD,CNS See book keywords and concepts | Phytotherapy, Research, vol.1 ,p.1,1988 77 . Horie, T., et al., Planta Medica, vol.55, p.506,1989
78. Lau, BHS, International Clinical Nutrition Reviews, vol.9, p.27,1989
79. Ip, C, etal., Nutr.Cancer, vol.17, p.279,1992
80. Dausch, JG, et al., Preventive Medicine, vol.19, p.346,1990 81 . Wargovich, MJ, etal., Cancer Letters, vol.64, p.39,1992
82. Belman, S, Carcinogenesis, vol.4, p. 1063,1983
83 . Steiner, M., et al., Amer.J.CIin.Nutr., vol.64, p.866,1996
84. Nakagawa, S., et al., phytotherapy Res., vol.1, p.1,1988
85. Dausch, JG, etal., Preventive Med., vol.19, p.346,1990 86 . | C. P. Khare See book keywords and concepts | Rational phytotherapy.)
Corn silk is being used in Homoeopathy. (Tincture: one part, by weight of the silk, to two of alcohol or fluid extract). Its principal use is indicated in irritable conditions of the urinary tract, ureters, bladder and urethra, as a diuretic in renal disorders. In a case study, patient's urine contained albumin, mucus, some blood with specific gravity 1010. Pus cells and granular epithelial cells were found in abundance. Corn silk fluid extract (one teaspoonful every four hours) was given. In less than a week there was visible improvement. | Michael T. Murray, N.D. See book keywords and concepts | Paper presented at the 4th International Congress on phytotherapy. Munich, Germany. September 10-13,1992. [Abstract SL54J; Sommer H. Improvement of psychovegetative complaints by hypericum. Paper presented at the 4th International Congress on phytotherapy. Munich, Germany. September 10-13,1992. [Abstract SL55]
17. Schlich D, Brauckmann F, and Schenk N: Treatment of depressive conditions with hypericum. Psychol 13, 440-444,1987.
18. Harrer G and Sommer H: Treatment of mild/moderate depressions with Hypericum. Phytomed 1, 3-8,1994.
19. James JS: AIDS Treatment News. Issue 74, February 24,1989. | James A. Duke, Ph.D. See book keywords and concepts | Principles and Practice of phytotherapy by Simon Mills and Kerry Bone (Edinburgh, Scotland: Churchill Livingstone, 1999).
Rational Phytotherapy: A Physician's Guide to Herbal Medicine, 3rd ed., by Volker Schulz, Hansel Rudolf, and Varro E. Tyler (Heidelberg, Germany: Springer Verlag, 1998).
Tyler's Herbs of Choice by James E. Robbers and Varro E. Tyler (Binghamton, N.Y.: Hawthorn Herbal Press, 1999). | Heather Boon, BScPhm, PhD and Michael Smith, BPharm, MRPharmS, ND See book keywords and concepts | Modern phytotherapy has expanded upon these historical uses. In addition, passionflower has been used for similar indications within the homeopathic tradition.3 While many species of Passiflora produce edible fruits, the ones commonly available are not from P. incarnata but rather P. edulis Sims.3
Current Medicinal Use
Passionflower products are now used primary to treat conditions associated with nervous tension, restlessness, irritability and insomnia. | Patrick Quillin, PhD,RD,CNS See book keywords and concepts | Phytotherapy Res., vol.1, p.1,1988
85. Dausch, JG, etal., Preventive Med., vol.19, p.346,1990 86 . You, WC, et al., J. Nat.Cancer Inst., vol.81, p.162,1989
87. Wargovich, MJ, etal., Cancer Letters, vol.64, p.39,1992
88. Marsh, CL, et al., J. Urology, vol.137, p.359, Feb.1987
89. Ip, C, et al., Nutrition and Cancer, vol.17, no.3, p.279,1992
90. Abdullah, TH, et al., J.Nat.Med.Assoc, vol.80, p.439,1988 91 . Amagase, H., etal., Carcinogenesis, vol.14, p.1627,1993
92. Yamasaki, T., et al., Cancer Letters, vol.59, p.89,1991
93. Hirao, Y„ etal., phytotherapy Research, vol.1, p.161,1987
94. |
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